Study database
Allocates by chance. It is the only design that can separate a cause from a mere co-occurrence.
HOHorse
In sixteen healthy horses the basal value reached 57.7 in October against 13.2 pg/ml in March, and older animals on starch-rich feed reached 60.0 against 15.7 pg/ml in similarly fed younger ones: the authors treat feeding as a possible confounder able to lead to wrongly classifying a horse as affected.
HOHorse
In a randomised experiment with nine Standardbreds, frequent load cycling and thirty minutes of walking improved measures of lamellar perfusion, whereas an hour of one-sided standing and sedation changed nothing measurable.
HOHorse
In the same model of an enforced offloading posture, inflammatory signalling in the lamellar tissue of the loaded limb was raised; the authors treat these pathways as possibly important, in the conditional, and rank them neither above nor below reduced perfusion as a cause.
HUHuman
In 58 people with chronic Achilles tendinopathy, eccentric training and heavy slow resistance training improved function and pain equally and durably out to 52 weeks, with no difference between the approaches.
HOHorse
In a randomised trial in 12 horses with career-ending flexor tendon injury, the treated tendons showed a better-ordered structure and a more normal composition than the control tendons after six months.
HUHuman
Randomised double-blind trial in 5,522 people with chronic coronary heart disease: the composite endpoint occurred in 6.8 per cent on low-dose colchicine and in 9.6 per cent on placebo, with a mean follow-up of 28.6 months.
HOHorse
Compared with dry hay, haylage lowered both the respirable dust (0.02 against 0.06 mg/m³) and beta-glucan and the neutrophils of the lung lavage, although in only seven horses.
HOHorse
Steamed hay and haylage lowered dust exposure to the same degree, yet only haylage reduced the neutrophils within six weeks and shifted the fatty acid profile towards the inflammation-resolving side.
HOHorse
When the fine particulate load of the ambient air fell from about 36 to about 7 micrograms per cubic metre, maximal oxygen uptake rose by 13.2%, with no difference between the corticosteroid and saline groups; the final exercise test in every animal followed an additional dose of salbutamol, and a comparison group kept under continued exposure was lacking.
HOHorse
Among 224 horses, 73.4% reached the defined success on inhaled ciclesonide against 43.2% on sham treatment; the authors stress the considerable placebo share.
HOHorse
Inhaled ciclesonide improved clinical signs and mast cell proportion in racehorses with moderate asthma even without any change in husbandry; the effect on neutrophilic forms remained unresolved.
HOHorse
Orally administered dexamethasone improved airway resistance, the nebulised form did not, while both routes suppressed the adrenal axis.
HOHorse
Triamcinolone injected into the hocks improved the lung function of asthmatic horses within a week, so that a joint treatment can delay the diagnosis of a lung disease.
HOHorse
Azithromycin added to inhaled fluticasone lowered airway neutrophilia more strongly, but improved neither lung function nor the regression of the smooth muscle over five months.
HOHorse
Horses with mild asthma showed interleukin-17 raised around fivefold and interleukin-10 lowered; dexamethasone lowered individual cytokines but did not change the cell profile, which points to continuing environmental exposure as the driver.
HOHorse
The animal's own adipose-derived cells did not achieve proof of equivalence with dexamethasone, but did improve clinical signs and individual inflammatory cytokines, with an effect over a year.
MUMultiple species
In the placebo group (58 dogs), owners saw an improvement in 39.7 per cent of cases and veterinary surgeons in 44.8 per cent, while the force plate showed no change in 46 of the 58 dogs.
HOHorse
In nine healthy ponies with no history of laminitis, all five animals treated with insulin developed laminitis in all four feet after a mean of 55.4 hours with blood glucose held normal, none of the four comparison animals did, and no digestive or general signs appeared.
HOHorse
Four of four Standardbred trotters treated with insulin developed laminitis in less than 48 hours and none of the four comparison animals did, even though all treated animals had a calculated insulin sensitivity in the normal range beforehand.
HOHorse
In a crossover trial in twelve ponies at one gram per kilogram per day, inulin changed blood glucose and insulin only slightly and fructose distinctly less than glucose, while laminitis-prone and normal ponies separated most clearly after glucose.
HOHorse
In groups of eight horses, five grams of oligofructose per kilogram alone made only two animals laminitic, preceding endotoxin made five, and endotoxin alone none, while both stimuli lowered insulin sensitivity without reinforcing one another.
HOHorse
Carried out in 18 horses in three groups, this paper documents the model: oligofructose doses regarded as triggering still produced measurable lamellar damage seven days later, which 72 hours of limb cooling reduced markedly.
HOHorse
Twelve ponies on plots sized for 1.5 per cent of bodyweight took in a calculated 2.33 per cent with immediate full access and gained 4.82 per cent in weight, against 1.59 to 1.82 per cent and 1.16 to 1.54 per cent where the area was allocated in portions.
HOHorse
At equal dry matter, soaked hay triggered the lowest insulin response, dry hay almost three times as high and haylage around six times as high, while the glucose response barely differed; this is the only randomised trial that compares soaked and dry hay directly.
HOHorse
A supplement and not the soaking was randomised, both groups receiving soaked hay; what remains usable is the measurement in the hay, with 38 per cent less non-structural carbohydrate and 6.78 per cent less digestible energy, together with the finding that the improvement in insulin sensitivity depended on the starting state and on weight loss.
HOHorse
In the untreated control arm 14 of 37 ponies with an existing insulin disorder developed laminitis on a starch-rich ration, whereas lowering insulin prevented it; only the fate of the control group matters here, and the substance tested is deliberately not discussed.
HUHuman
Among more than 238,000 adults analysed, stating in the report how common a finding is in people without symptoms did not measurably change the use of health care services, but slightly reduced the prescribing of opioids.
HOHorse
In a randomised crossover trial in eight horses, two anti-crib collars and a muzzle lowered crib-biting with no difference between them and with no detectable rise on the day after removal, while surgically placed gum rings in six horses worked only temporarily and were probably painful; the research group calls for the housing conditions to be addressed rather than the behaviour prevented mechanically.
HOHorse
An anti-crib collar prevented crib-biting in six of eight horses over 24 hours, and on the following day these horses crib-bit clearly more often than the comparison horses and than before, which the authors read as an increase in internal motivation during prevention.
HOHorse
19 young horses that had begun crib-biting shortly before had clearly more damaged and more inflamed stomachs at the outset than 16 unaffected animals, together with a lower faecal pH; a randomly allocated acid-buffering ration improved the stomach findings, but crib-biting declined in both groups, only somewhat more strongly on that ration.
HOHorse
In two experiments on naturally infected horses, efficacy against small strongyles was 100 per cent after oral dosing and 36 to 64 per cent after intramuscular injection, although blood levels were higher there: what decides is the exposure of the worms in the gut lumen, not the plasma concentration.
HOHorse
In 36 grazing horses with post-mortem work after two and five weeks, the disappearance of eggs does not mirror the disappearance of the parasites: very high efficacy against adult worms (99.9 and 99.7 per cent after two weeks, 88.3 and 57.6 per cent after five) alongside nil efficacy against luminal larval stages after five weeks; larval counts were reported for moxidectin only.
HOHorse
In a blinded experiment on 18 young horses with complete worm counts, the five-day fenbendazole regime lowered egg counts by 44.6 per cent but reached 71.2 per cent against late mucosal larvae, while moxidectin reached 99.9 per cent on eggs and 85.2 per cent on those same stages: egg reduction and larval reduction move independently of one another.
HOHorse
In 82 treated mares egg reduction after 14 days was 99.9 per cent against 41.9 per cent, yet after 45 days the second group already exceeded its starting values while the first stayed below them for more than 90 days: a check value at two weeks says nothing about how long the effect lasts.
HOHorse
In 18 young horses larvicidal treatment produced only a mild local inflammatory reaction with no systemic response, which the authors rate as of little clinical importance; they recall the case fatality of larval cyathostominosis of around 50 per cent and do not test what egg counts can show.
HOHorse
In 25 foals with diarrhoea the transfer of gut flora appeared safe but changed neither survival nor resolution of the diarrhoea; three foals originally allocated to the control group were switched to treatment during the trial, which weakens the randomised comparison.
HOHorse
In a randomised field trial in 38 newborn foals the effects of a multi-strain product on the microbiome remained limited, and the proportion of lactobacilli and bifidobacteria did not rise while it was given.
HOHorse
In 14 horses with acute enterocolitis the severity and duration of the illness were milder and shorter under a yeast than under placebo, the yeast passing through the digestive tract without colonising it durably.
HUHuman
In 155 adults with poor sleep, insomnia severity fell by 3.9 points after four weeks against 2.3 points on placebo; the effect was small, and in an exploratory analysis people with a low dietary magnesium intake benefited more.
HUHuman
Eighty adults over 21 days: readings for deep and REM sleep captured with a measurement ring, along with several self-reported measures of mood and daytime form, came out better than on placebo; co-authors are from the ingredient supplier.
HOHorse
Randomised dietary trial in six affected and six healthy geldings: headshaking frequency fell by 52 per cent on magnesium and by 64 per cent on magnesium with boron, but the pelleted base feed without any addition already lowered it by 44 per cent.
HOHorse
In a double-blind randomised trial in 32 Breton horses over seventy days the mite count fell markedly further under the combination, but the skin changes improved only to a limited degree and not at all in the most severely affected horses, which the authors attribute to the short study duration.
HOHorse
In a placebo-controlled trial in 19 draught horses, itching and mange lesions had clearly receded after mite treatment, but the skin fold score as a measure of established tissue change had not, and in three of the ten treated horses mites reappeared after 24 weeks.
HOHorse
Of 37 randomised horses only 21 completed the study; the preparation containing kunzea oil clearly reduced the lesion area after seven days, which the comparison antifungal did not, while neither fungal diagnostics nor a placebo group nor follow-up for relapse was provided for.
HUHuman
An ester that releases propionate specifically in the colon acutely raised satiety hormones and, over 24 weeks in 60 overweight adults, reduced weight gain, abdominal fat and liver fat compared with the inulin control.
HUHuman
In a 21-day crossover study with 20 healthy adults, a high-fibre diet raised plasma butyrate from 2.02 to 2.85 micromoles per litre, and the numbers of B cells and of certain T cells in the blood fell; clinical significance unclear.
HUHuman
In 80 healthy adults, replacing white flour with high-amylose wheat flour raised faecal butyrate excretion by 38 per cent compared with the control, while total fatty acids and stool weight remained unchanged.
HUHuman
In 54 children with obesity, 96 per cent on sodium butyrate over six months reached the predefined target of a reduction in body mass index, against 56 per cent on placebo, with additionally lower waist circumference, insulin and interleukin-6.
HUHuman
In 36 people with active ulcerative colitis, sodium butyrate over twelve weeks lowered faecal calprotectin and the high-sensitivity inflammatory marker in the blood and improved sleep and quality-of-life scores; small sample, single centre.
HOHorse
In 20 four-year-old Warmblood stallions over nine weeks, plasma metabolites did not differ between a high-starch and a high-fat ration; only exploratory behaviour tended to diverge between the groups.
HOHorse
In 41 already diseased horses over one year, vaccination reduced neither the frequency of relapse (7 of 20 against 12 of 21) nor the progression in a way that could be secured; only the interval to the first relapse lengthened markedly, and the authors record that the data do not support routine use as an accompanying treatment.
HOHorse
In twelve horses randomly allocated to four settings, a rise in heart rate, a fall in heart rate variability and a rise in eye temperature appeared only with the strap fully closed, while chewing was already reduced from one finger onwards and a marked catch-up behaviour followed unbridling.
HOHorse
In a randomised, blinded trial with sixteen ridden horses the measured pharyngeal diameter remained unchanged, while the amount of secretion, the lateral deviation of the epiglottic folds and collapse of the pharyngeal wall increased with the tight strap and the pain ethogram score rose, without exceeding the threshold in any horse.
HOHorse
In eleven dressage horses with the noseband set to two fingers, the pressure under the strap did not differ between snaffle and double bridle, while pressure and force at the poll were higher with the double bridle and rein tension lower; only the order of the two bridles within the same horse was randomised.
HOHorse
The only randomised trial of lying deprivation in the horse showed no statistically meaningful cognitive disadvantage in ten Lusitanos after 72 hours without lying down, only trends towards longer times in both tasks.
HOHorse
In 45 horses across three groups over 14 months, no statistically secure difference was found between mistletoe extract and placebo, neither with oral nor with subcutaneous administration, while oral administration was well tolerated.
HOHorse
In 53 horses with 444 sarcoids, lesions regressed fully or in part in 13 of 32 treated horses against 3 of 21 control horses; the authors called the extract safe and effective in the clinically diagnosed sarcoid, while the complete disappearance of individual lesions fell short of statistical confirmation.
HOHorse
In 34 Icelandic horses (19 vaccinated, 15 on a dummy preparation) 47 per cent of the vaccinated animals halved and 21 per cent improved by three quarters their lesion score, against 13 and 0 per cent on placebo, with 17 of the 19 vaccinated horses forming antibodies and improvement depending on a minimum level: a first successful but partial immunotherapy, not a cure.
HOHorse
In 20 horses over one year the clinical values never differed between desensitisation and sham treatment; both groups improved to a similar degree, which the authors attribute to the repellent applied weekly in both groups.
HOHorse
In a blinded crossover trial in 20 horses all four values recorded by the veterinary surgeons, itch included, improved against baseline and against the dummy preparation, while the keepers reported complete disappearance in 85 per cent and only one of four tissue samples was entirely unremarkable.
HOHorse
In the half-body comparison over the first four weeks the skin lesions on the treated side improved against the untreated side, while itch and coat quality did not change meaningfully; from day 28 both sides were treated, so that the later comparison was no longer controlled.
SPSpecies-independent
1,689 randomised manuscripts: the editorial request to complete an ARRIVE checklist produced full compliance in neither group; only the information on housing improved, from 52.1 to 74.1 per cent.
HOHorse
Randomised, blinded study in 17 horses with an induced lesion of the superficial digital flexor tendon: intralesional microRNA treatment lowered collagen 3 transcripts, reduced the cross-sectional area of the lesion and improved the histological score compared with placebo.
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