Study database
Allocates by chance. It is the only design that can separate a cause from a mere co-occurrence.
HUHuman
In 58 people with chronic Achilles tendinopathy, eccentric training and heavy slow resistance training improved function and pain equally and durably out to 52 weeks, with no difference between the approaches.
HOHorse
In a randomised trial in 12 horses with career-ending flexor tendon injury, the treated tendons showed a better-ordered structure and a more normal composition than the control tendons after six months.
HUHuman
Randomised double-blind trial in 5,522 people with chronic coronary heart disease: the composite endpoint occurred in 6.8 per cent on low-dose colchicine and in 9.6 per cent on placebo, with a mean follow-up of 28.6 months.
HOHorse
Compared with dry hay, haylage lowered both the respirable dust (0.02 against 0.06 mg/m³) and beta-glucan and the neutrophils of the lung lavage, although in only seven horses.
HOHorse
Steamed hay and haylage lowered dust exposure to the same degree, yet only haylage reduced the neutrophils within six weeks and shifted the fatty acid profile towards the inflammation-resolving side.
HOHorse
When the fine particulate load of the ambient air fell from about 36 to about 7 micrograms per cubic metre, maximal oxygen uptake rose by 13.2%, with no difference between the corticosteroid and saline groups; the final exercise test in every animal followed an additional dose of salbutamol, and a comparison group kept under continued exposure was lacking.
HOHorse
Among 224 horses, 73.4% reached the defined success on inhaled ciclesonide against 43.2% on sham treatment; the authors stress the considerable placebo share.
HOHorse
Inhaled ciclesonide improved clinical signs and mast cell proportion in racehorses with moderate asthma even without any change in husbandry; the effect on neutrophilic forms remained unresolved.
HOHorse
Orally administered dexamethasone improved airway resistance, the nebulised form did not, while both routes suppressed the adrenal axis.
HOHorse
Triamcinolone injected into the hocks improved the lung function of asthmatic horses within a week, so that a joint treatment can delay the diagnosis of a lung disease.
HOHorse
Azithromycin added to inhaled fluticasone lowered airway neutrophilia more strongly, but improved neither lung function nor the regression of the smooth muscle over five months.
HOHorse
Horses with mild asthma showed interleukin-17 raised around fivefold and interleukin-10 lowered; dexamethasone lowered individual cytokines but did not change the cell profile, which points to continuing environmental exposure as the driver.
HOHorse
The animal's own adipose-derived cells did not achieve proof of equivalence with dexamethasone, but did improve clinical signs and individual inflammatory cytokines, with an effect over a year.
MUMultiple species
In the placebo group (58 dogs), owners saw an improvement in 39.7 per cent of cases and veterinary surgeons in 44.8 per cent, while the force plate showed no change in 46 of the 58 dogs.
HUHuman
In 155 adults with poor sleep, insomnia severity fell by 3.9 points after four weeks against 2.3 points on placebo; the effect was small, and in an exploratory analysis people with a low dietary magnesium intake benefited more.
HUHuman
Eighty adults over 21 days: readings for deep and REM sleep captured with a measurement ring, along with several self-reported measures of mood and daytime form, came out better than on placebo; co-authors are from the ingredient supplier.
HOHorse
Randomised dietary trial in six affected and six healthy geldings: headshaking frequency fell by 52 per cent on magnesium and by 64 per cent on magnesium with boron, but the pelleted base feed without any addition already lowered it by 44 per cent.
HUHuman
An ester that releases propionate specifically in the colon acutely raised satiety hormones and, over 24 weeks in 60 overweight adults, reduced weight gain, abdominal fat and liver fat compared with the inulin control.
HUHuman
In a 21-day crossover study with 20 healthy adults, a high-fibre diet raised plasma butyrate from 2.02 to 2.85 micromoles per litre, and the numbers of B cells and of certain T cells in the blood fell; clinical significance unclear.
HUHuman
In 80 healthy adults, replacing white flour with high-amylose wheat flour raised faecal butyrate excretion by 38 per cent compared with the control, while total fatty acids and stool weight remained unchanged.
HUHuman
In 54 children with obesity, 96 per cent on sodium butyrate over six months reached the predefined target of a reduction in body mass index, against 56 per cent on placebo, with additionally lower waist circumference, insulin and interleukin-6.
HUHuman
In 36 people with active ulcerative colitis, sodium butyrate over twelve weeks lowered faecal calprotectin and the high-sensitivity inflammatory marker in the blood and improved sleep and quality-of-life scores; small sample, single centre.
HOHorse
In 20 four-year-old Warmblood stallions over nine weeks, plasma metabolites did not differ between a high-starch and a high-fat ration; only exploratory behaviour tended to diverge between the groups.
SPSpecies-independent
1,689 randomised manuscripts: the editorial request to complete an ARRIVE checklist produced full compliance in neither group; only the information on housing improved, from 52.1 to 74.1 per cent.
HOHorse
Randomised, blinded study in 17 horses with an induced lesion of the superficial digital flexor tendon: intralesional microRNA treatment lowered collagen 3 transcripts, reduced the cross-sectional area of the lesion and improved the histological score compared with placebo.
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